What is Roxicodone?

Roxicodone is a prescription opioid pain medication used to treat moderate to severe pain when other treatments, like non-opioid pain relievers, are ineffective or not tolerated.

  • Available as immediate-release tablets in 5 mg, 15 mg, and 30 mg strengths.

  • Generic name: Oxycodone.

  • Can be ordered online with a valid prescription.

  • Switching from immediate-release to extended-release oxycodone requires close monitoring for drowsiness or slow breathing.

Important Information

  • Do not use if you have:

    • Severe asthma or breathing problems

    • Bowel or stomach blockage

  • Misuse or abuse can lead to overdose or death.

  • Long-term use during pregnancy may cause withdrawal symptoms in newborns, which can be fatal.

  • Combining with alcohol or other sedatives can result in fatal side effects.

Before Taking Roxicodone

Avoid Roxicodone if allergic to it. Consult your doctor if you have a history of:

  • Breathing problems, including sleep apnea

  • Head injury or seizures

  • Drug or alcohol addiction, or mental illness

  • Liver or kidney disease

  • Urination problems

  • Gallbladder, pancreas, or thyroid issues

Pregnancy and breastfeeding:

  • Can cause neonatal opioid dependence.

  • Avoid breastfeeding while taking this medication; it may cause severe drowsiness or slow breathing in infants.

How to Take Roxicodone

  • Take exactly as prescribed. Follow your prescription label and medication guide.

  • Do not exceed the prescribed dose or take it longer than recommended.

  • Take with food to reduce nausea.

  • Swallow tablets whole; do not crush, chew, or dissolve.

  • Never inject or inhale crushed tablets; it can be fatal.

  • Do not stop abruptly. Taper dose under medical supervision to prevent withdrawal, which may include:

    • Irritability, insomnia, restlessness

    • Chills, muscle/joint pain, sweating

    • Nausea, vomiting, diarrhea

    • Increased heart rate and blood pressure

Storage: Keep at room temperature, away from heat, moisture, and light. Track your supply carefully to prevent misuse.

Dosage

  • Opioid-naive adults: 5–15 mg orally every 4–6 hours as needed for pain.

  • Adjust based on individual response.

  • Take on a regular schedule every 4–6 hours for chronic severe pain.

Overdose

Signs of overdose may include:

  • Pinpoint pupils

  • Severe drowsiness

  • Slow or stopped breathing

  • Coma

Action: Keep naloxone accessible. Caregivers can administer it if breathing stops. Seek emergency help immediately.

What to Avoid

  • Alcohol, sedatives, or other opioids – may slow breathing and cause death.

  • Grapefruit or grapefruit juice – may increase side effects.

  • Driving or operating machinery until you know how the medication affects you.

  • Medication errors – always verify brand and strength from your pharmacy.

Side Effects

Common side effects:

  • Drowsiness, dizziness, headache, tiredness

  • Constipation, stomach pain, nausea, vomiting

Serious side effects:

  • Noisy, shallow, or stopped breathing

  • Slow or weak heartbeat

  • Lightheadedness, confusion, or unusual behavior

  • Seizures

  • Low cortisol: nausea, vomiting, fatigue, dizziness, loss of appetite

  • High serotonin: agitation, hallucinations, fever, sweating, muscle stiffness, tremors, vomiting, diarrhea

Drug Interactions

Roxicodone may interact with:

  • Other pain medications or opioids

  • Phenothiazines (for serious mental disorders)

  • Monoamine oxidase inhibitors (MAOIs)

  • Sleeping pills, tranquilizers, or anxiety medications

  • Antihistamines or anti-nausea medications

  • Antidepressants

Other interactions include:

  • Cold or allergy drugs, bronchodilators, or diuretics

  • Medications for motion sickness, IBS, or overactive bladder

  • Sedatives such as Valium, Xanax, Klonopin, Versed

  • Muscle relaxants or sleep aids